ECCO consensus: Evidence-based use of 6-thioguanine therapy in Crohn's disease?
نویسندگان
چکیده
منابع مشابه
ECCO consensus: evidence-based use of 6-thioguanine therapy in Crohn's disease?
With great interest, we have read the updated ECCO consensus on the treatment of Crohn's disease.1 Being highly interested in research on the clinical use of thiopurines, we feel that several additional commentsmay give opportunity to a more balanced, evidence-based conclusion on the discarded use of 6-thioguanine as an alternative thiopurine. Firstly, the authors state that 6-thioguanine is th...
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SUMMARY Mice treated simultaneously with 1-0-D-arabinofuranosyl-cytosine (ara-C) and 6-thioguanine (6-TG) were protected from the lethal effects of 6-TG. No protection was afforded if ara-C was given 16 hr before the 6-TG. DNA synthesis in mouse bone marrow was immediately depressed to 3 to 12% of that of control in various experiments, after treatment with ara-C, 10 to 20 mg/kg; it then reboun...
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Ascites cell tumors were found to cleave thioguanine riboside relatively rapidly. In tumor cell lines lacking the ribonucleotide pyrophosphorylase necessary for formation of thioguanine ribonucleotide, thioguanine riboside was converted to nucleotide to a small extent. This nucleotide formation was enhanced, after a short time lag, by 9-methyl thioguanine. The nucleoside, adenine arabinoside, w...
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ژورنال
عنوان ژورنال: Journal of Crohn's and Colitis
سال: 2010
ISSN: 1873-9946
DOI: 10.1016/j.crohns.2010.07.005